Researchers at Stanford University have demonstrated that a vaccine with induced pluripotent stem cells (or iPSCs) was able to prevent tumor growth in a wide range of cancers, including mesothelioma. An online report published in Cell Stem Cell details how taking a blood sample and injecting the iPSCs made from it into the same person may work to prevent future cancers.
Mesothelioma is a highly aggressive cancer that is nearly always linked to asbestos exposure. The deadly disease can remain in a latency period for decades before developing in the lungs, but when a diagnosis is made, the prognosis is grim. Mesothelioma victims have traditionally relied on chemotherapy, radiation, gene therapies, and surgery to alleviate the painful symptoms and slow the pace of the disease.
The Stanford research team found immune activation and rejection of mesothelioma in a vaccinated group of mice. Study investigator Dr. Joseph Wu, the director of the Stanford Cardiovascular Institute and an endowed professor in the Department of Medicine and Department of Radiology at the Stanford School of Medicine, told the Cancer Network that he can envision a patient-specific vaccine which can be used at various stages of life.
“You would vaccinate a high-risk patient at a certain age when they become more vulnerable to developing cancer, say 70 years, to give their immune system a boost to target cancers cells or provide memory immunity against possible future cancers,” Dr. Wu said.
According to the results posted on Cell Stem Cell, the highlights of the research report findings include:
- Irradiated iPSCs prevent tumor growth in murine models of breast, lung, and skin cancer
- iPSC vaccines target shared antigens between iPSCs and cancer cells
- iPSC vaccines promote a humoral and cell-mediated anti-tumor immune profile
- As an adjuvant cancer therapy, iPSC vaccination can reactivate the immune system
The vaccine also could be used as adjuvant therapy following several symptom-relieving procedures, including surgery, chemotherapy, and radiation.
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Mesothelioma Accountability and Justice
Mesothelioma is almost always caused by asbestos exposure that invariably results from the dangerous actions of others, whether they be employers, building owners, contractors, or manufacturing companies. The American legal system is designed to enable compensation and justice for those who were needlessly harmed.
The mesothelioma lawyers of Cooney & Conway have spent decades handling asbestos lawsuits, and have obtained answers, and accountability, for mesothelioma victims and their families. For more information and to schedule a consultation contact Cooney & Conway by calling told free 800-322-5573, or simply fill out the Case Evaluation contact information form located on this page.